The story begins in late-19th century Europe, where a new technology has spread that allows dead bodies to be installed with an artiﬁcial soul to create "Frankensteins"—corpses which can be utilized as laborers and soldiers—and this new technology has spurred an industrial revolution across the Western world.
A medical student in London named John H. Watson (who will later become a partner to Sherlock Holmes) is scouted by a government agency to serve as a secret agent, and receives orders to inﬁltrate Afghanistan as an army medic. Watson discovers that Frankensteins are being used in huge numbers for military purposes in Afghanistan. He gradually becomes aware of the fact that "The One," the original creature created nearly 100 years earlier by the genius scientist Victor Frankenstein, is still alive somewhere in the world, and seems to be orchestrating some sort of plot. Watson leaves Afghanistan and crosses over to post-Meiji Restoration Japan to meet up with Rhett Butler and the lovely Hadaly of the Pinkerton Detective Agency. In pursuit of The One, they head for America, which is still recovering from the Civil War, and ﬁnally catch up with The One.
The One's plot is to implement an "All-Mankind Resurrection Initiative." What is life? What is consciousness? What is a soul? Young Watson's quest confronts him with questions that lead him to a shocking conclusion.
The prologue and plot of this novel were created by the brilliant SF writer Project (Keikaku) Itoh, who passed away without having a chance to ﬁnish the masterpiece he started. Therein entered his friend Toh EnJoe, a prize-winning author in his own right, who promised to carry out Itoh's dying wish. EnJoe became something of a ghost, slipping into the mind of his deceased friend to complete the story, which became a sensation in the media even before its release. This blockbuster hit is the product of a miraculous encounter between the rare talents of two of modern Japan's finest writers.